Use a full-size pickup instead of a compact when you repeatedly need passenger space, cargo dimensions, or loaded capability that the compact cannot provide. A larger cab may suit adult passengers, a different bed may accommodate bulky equipment, and a properly equipped full-size truck may handle a trailer beyond the compact's limits. Each advantage needs to be checked on the actual configuration.
Here, the everyday comparison is a light-duty full-size pickup with a compact pickup; moving up in size does not automatically mean choosing heavy-duty. The larger truck earns its place when it solves a recurring problem. If the compact already fits the people and loads, easier parking and access may be more valuable than capacity you rarely use.