Heavy-duty pickups are generally full-size trucks, so the useful comparison is heavy-duty versus light-duty full-size pickups. A typical light-duty full-size model balances passenger use, everyday driving, and hauling. An HD model is engineered for more demanding carrying and towing work through a different combination of chassis, axles, suspension, powertrain, cooling, and equipment.
That difference is about supported workload, not simply body size or engine power. Two trucks with similar-looking cabs can have very different capacities. Conversely, an HD badge does not make every configuration superior in every measurement: the exact loading label and towing documentation remain decisive.