Safety factors matter in a full-size pickup because its size, load, and visibility can change substantially between an empty commute and a family towing trip. A tall driving position can help you see farther ahead while still leaving areas close to the vehicle hidden. Passengers, cargo, and a trailer also change the weights the truck must support and control.
Start with a suitable vehicle and load, then use restraints, sound tires and brakes, secure cargo, and deliberate low-speed maneuvering. Cameras and driver assistance are useful aids with defined limits. A large truck is not a substitute for checking the space around it or for adapting to the load and road.