Safety in a heavy-duty pickup depends on controlling the weight it carries and pulls. The truck's size and power do not remove the need for correct loading, sound tires, effective brakes, visibility, and compatible hitch equipment. A capable truck can still be overloaded at one axle or paired with a trailer it cannot safely support.
The practical safety check follows the complete trip: verify the loaded weights, inspect the truck and trailer, set up the connection correctly, and drive for the road and weather. Electronic assistance can help with specific tasks, but it cannot turn an unsuitable combination into a suitable one.